You can use code below:
protected void ASPxGridView1_CommandButtonInitialize(object sender, ASPxGridViewCommandButtonEventArgs e) { ASPxGridView grid = (sender as ASPxGridView); if (e.ButtonType == ColumnCommandButtonType.SelectCheckbox) { if(grid.GetRowValues(e.VisibleIndex, "ID").ToString() == "1") { e.Enabled = false; } else { e.Enabled = true; } } }